I’ve been working on a CoffeeScript web app in RailwayJS which is a rails-alike framework for nodejs built on top of Express.
One cool thing about RailwayJS is that you can write most of your code (not views?) in CoffeeScript instead of JavaScript. The generators, etc. will do the right thing if you give them the --coffee switch.
RailwayJS also has ORM with MongoDB and localization baked in.
#!/usr/bin/env coffee
app = module.exports = require('railway').createServer()
if not module.parent
port = process.env.PORT or 3000
app.listen port
console.log "Railway server listening on port %d within %s environment", port, app.settings.env
